Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI103910

COMBINED DRUG TREATMENT OF TUBERCULOSIS. I. PREVENTION OF EMERGENCE OF MUTANT POPULATIONS OF TUBERCLE BACILLI RESISTANT TO BOTH STREPTOMYCIN AND ISONIAZID IN VITRO

Maurice L. Cohn, Gardner Middlebrook, and William F. Russell Jr.

Department of Research and Laboratories, National Jewish Hospital at Denver, Colo.

Department of Medicine, University of Colorado School of Medicine, Denver, Colo.

Department of Microbiology, University of Colorado School of Medicine, Denver, Colo.

Find articles by Cohn, M. in: PubMed | Google Scholar

Department of Research and Laboratories, National Jewish Hospital at Denver, Colo.

Department of Medicine, University of Colorado School of Medicine, Denver, Colo.

Department of Microbiology, University of Colorado School of Medicine, Denver, Colo.

Find articles by Middlebrook, G. in: PubMed | Google Scholar

Department of Research and Laboratories, National Jewish Hospital at Denver, Colo.

Department of Medicine, University of Colorado School of Medicine, Denver, Colo.

Department of Microbiology, University of Colorado School of Medicine, Denver, Colo.

Find articles by Russell, W. in: PubMed | Google Scholar

Published August 1, 1959 - More info

Published in Volume 38, Issue 8 on August 1, 1959
J Clin Invest. 1959;38(8):1349–1355. https://doi.org/10.1172/JCI103910.
© 1959 The American Society for Clinical Investigation
Published August 1, 1959 - Version history
View PDF
Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1349
page 1349
icon of scanned page 1350
page 1350
icon of scanned page 1351
page 1351
icon of scanned page 1352
page 1352
icon of scanned page 1353
page 1353
icon of scanned page 1354
page 1354
icon of scanned page 1355
page 1355
Version history
  • Version 1 (August 1, 1959): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts