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Research Article Free access | 10.1172/JCI101775

CHEMICAL, CLINICAL AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXIII. THE COAGULATION DEFECT IN HEMOPHILIA: THE EFFECT IN VITRO AND IN VIVO ON THE COAGULATION TIME IN HEMOPHILIA OF A PROTHROMBIN AND FIBRINOGEN-FREE NORMAL PLASMA AND ITS DERIVED PROTEIN FRACTIONS 123

Jessica H. Lewis, J. P. Soulier, and F. H. L. Taylor

Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, Boston

Department of Medicine, Harvard Medical School, Boston

1

This is paper No. 45 in the “Studies of Plasma Proteins” of the Harvard Medical School, on products developed by the Department of Physical Chemistry, from blood collected by the American Red Cross.

2

The expenses of this investigation were defrayed in part by gift from the Smith, Kline and French Laboratories, Philadelphia, and in part by a grant “In recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

3

We are indebted to Professor Edwin J. Cohn and Dr. John T. Edsall for furnishing the material on which these observations were made.

Find articles by Lewis, J. in: PubMed | Google Scholar

Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, Boston

Department of Medicine, Harvard Medical School, Boston

1

This is paper No. 45 in the “Studies of Plasma Proteins” of the Harvard Medical School, on products developed by the Department of Physical Chemistry, from blood collected by the American Red Cross.

2

The expenses of this investigation were defrayed in part by gift from the Smith, Kline and French Laboratories, Philadelphia, and in part by a grant “In recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

3

We are indebted to Professor Edwin J. Cohn and Dr. John T. Edsall for furnishing the material on which these observations were made.

Find articles by Soulier, J. in: PubMed | Google Scholar

Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, Boston

Department of Medicine, Harvard Medical School, Boston

1

This is paper No. 45 in the “Studies of Plasma Proteins” of the Harvard Medical School, on products developed by the Department of Physical Chemistry, from blood collected by the American Red Cross.

2

The expenses of this investigation were defrayed in part by gift from the Smith, Kline and French Laboratories, Philadelphia, and in part by a grant “In recognition of Dr. Francis W. Peabody's services to the Foundation” by the Ella Sachs Plotz Foundation.

3

We are indebted to Professor Edwin J. Cohn and Dr. John T. Edsall for furnishing the material on which these observations were made.

Find articles by Taylor, F. in: PubMed | Google Scholar

Published November 1, 1946 - More info

Published in Volume 25, Issue 6 on November 1, 1946
J Clin Invest. 1946;25(6):876–879. https://doi.org/10.1172/JCI101775.
© 1946 The American Society for Clinical Investigation
Published November 1, 1946 - Version history
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