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ResearchIn-Press PreviewMetabolismOncology
Open Access | 
10.1172/JCI165028
Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase-deficient renal cell carcinoma
Liang Zheng,1 Zi-Ran Zhu,1 Tal Sneh,2 Weituo Zhang,3 Zao-Yu Wang,4 Guang-Yu Wu,4 Wei He,4 Hong-Gang Qi,5 Hang Wang,6 Xiao-Yu Wu,1 Jonatan Fernández-García,2 Ifat Abramovich,2 Yun-Ze Xu,7 Jin Zhang,7 and Eyal Gottlieb8
1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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1Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
3Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University, Shanghai, China
4Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
6Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
7Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
8Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, United States of America
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Published April 13, 2023 - More info
Copyright © 2023, Zheng et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)