Work led by Andrew Tobin at the University of Leicester tested two drugs that specifically target the M1 muscarinic acetylcholine receptor in a mouse model of prion disease and discovered that the treatments reversed cognitive decline.
Published December 19, 2016

Recent work by Jonathan Kurie’s lab at MD Anderson Cancer Center has shown that the epithelial-to-mesenchymal transition is accompanied a compaction of Golgi organelles that may enhance pro-metastatic vesicle trafficking...
Published November 21, 2016

Work from Jonathan Stamler’s lab at Case Western Reserve University shows that S-nitrosylation plays a key role in protecting against ischemic cardiac injury and heart failure...
Published November 14, 2016

Work led by Stephen Galli at Stanford University has determined that expression of the E3 ubiquitin ligase RAB guanine nucleotide exchange factor 1 (RABGEF1) in keratinocytes plays a crucial role in maintaining epidermal barrier function...
Published November 7, 2016

In the accompanying video, author Wang Min describes how TAMs are recruited to ovarian tumor cells in the peritoneal environment to form spheroids that drive the early stages of metastasis...
Published October 10, 2016

Work led by Jian Yu at the University of Pittsburgh School of Medicine has demonstrated that blocking the G1/S transition with an inhibitor of cyclin-dependent kinase 4/6 protects mice against radiation-induced intestinal damage...
Published October 4, 2016

Research led by James Fagin at Memorial Sloan Kettering has demonstrated that potent, sustained ERK inhibition leads to greater improvements in the clinical response to radioiodine therapy in resistant tumors...
Published September 26, 2016

Alain de Bruin, Gustavo Leone, and colleagues find that the E2F8-mediated transcriptional repression in the developing liver suppresses hepatocellular carcinoma later in life …
Published July 25, 2016

Xie and colleagues demonstrate that the transcription factor TBX4 contributes to pathogenic fibroblast accumulation during lung fibrosis by providing cellular progenitors and enhancing fibroblast invasiveness…
Published July 11, 2016

Quan Lui and colleagues reveal that delivery of donor MHC-containing exosomes from donor DCs to recipient DCs drive allograft-targeting immune responses…
Published June 27, 2016