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Genetics

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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Annette Robichaud, … , Marco Conti, Chi-Chung Chan
Annette Robichaud, … , Marco Conti, Chi-Chung Chan
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):1045-1052. https://doi.org/10.1172/JCI15506.
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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

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Abstract

Research Article

Authors

Annette Robichaud, Panagiota B. Stamatiou, S.-L.Catherine Jin, Nicholas Lachance, Dwight MacDonald, France Laliberté, Susana Liu, Zheng Huang, Marco Conti, Chi-Chung Chan

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Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms
Kathryn G. Schuff, … , Sylvia L. Asa, Malcolm J. Low
Kathryn G. Schuff, … , Sylvia L. Asa, Malcolm J. Low
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):973-981. https://doi.org/10.1172/JCI15912.
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Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms

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Abstract

Research Article

Authors

Kathryn G. Schuff, Shane T. Hentges, Michele A. Kelly, Nadine Binart, Paul A. Kelly, P. Michael Iuvone, Sylvia L. Asa, Malcolm J. Low

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Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4
Hairong Peng, … , James Cummins, Johnny Huard
Hairong Peng, … , James Cummins, Johnny Huard
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):751-759. https://doi.org/10.1172/JCI15153.
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Synergistic enhancement of bone formation and healing by stem cell–expressed VEGF and bone morphogenetic protein-4

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Abstract

Research Article

Authors

Hairong Peng, Vonda Wright, Arvydas Usas, Brian Gearhart, Hsain-Chung Shen, James Cummins, Johnny Huard

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A mouse model of human oral-esophageal cancer
Oliver G. Opitz, … , Hiroshi Nakagawa, Anil K. Rustgi
Oliver G. Opitz, … , Hiroshi Nakagawa, Anil K. Rustgi
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):761-769. https://doi.org/10.1172/JCI15324.
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A mouse model of human oral-esophageal cancer

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Abstract

Research Article

Authors

Oliver G. Opitz, Hideki Harada, Yasir Suliman, Ben Rhoades, Norman E. Sharpless, Ralph Kent, Levy Kopelovich, Hiroshi Nakagawa, Anil K. Rustgi

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PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
Joëlle Dupont, … , Lothar Hennighausen, Derek LeRoith
Joëlle Dupont, … , Lothar Hennighausen, Derek LeRoith
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):815-825. https://doi.org/10.1172/JCI13829.
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PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

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Abstract

Research Article

Authors

Joëlle Dupont, Jean Pierre Renou, Moshe Shani, Lothar Hennighausen, Derek LeRoith

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Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function
Sara K. Hansen, … , Jorge Ferrer, Torben Hansen
Sara K. Hansen, … , Jorge Ferrer, Torben Hansen
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):827-833. https://doi.org/10.1172/JCI15085.
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Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

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Abstract

Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and HNF-1α impair insulin secretion and cause maturity onset diabetes of the young (MODY). HNF-4α is known to be an essential positive regulator of HNF-1α. More recent data demonstrates that HNF-4α expression is dependent on HNF-1α in mouse pancreatic islets and exocrine cells. This effect is mediated by binding of HNF-1α to a tissue-specific promoter (P2) located 45.6 kb upstream from the previously characterized Hnf4α promoter (P1). Here we report that the expression of HNF-4α in human islets and exocrine cells is primarily mediated by the P2 promoter. Furthermore, we describe a G → A mutation in a conserved nucleotide position of the HNF-1α binding site of the P2 promoter, which cosegregates with MODY. The mutation results in decreased affinity for HNF-1α, and consequently in reduced HNF-1α–dependent activation. These findings provide genetic evidence that HNF-1α serves as an upstream regulator of HNF-4α and interacts directly with the P2 promoter in human pancreatic cells. Furthermore, they indicate that this regulation is essential to maintain normal pancreatic function.

Authors

Sara K. Hansen, Marcelina Párrizas, Maria L. Jensen, Stepanka Pruhova, Jakob Ek, Sylvia F. Boj, Anders Johansen, Miguel A. Maestro, Francisca Rivera, Hans Eiberg, Michal Andel, Jan Lebl, Oluf Pedersen, Jorge Ferrer, Torben Hansen

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Craniosynostosis in transgenic mice overexpressing Nell-1
Xinli Zhang, … , Naoaki Saito, Kang Ting
Xinli Zhang, … , Naoaki Saito, Kang Ting
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):861-870. https://doi.org/10.1172/JCI15375.
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Craniosynostosis in transgenic mice overexpressing Nell-1

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Abstract

Research Article

Authors

Xinli Zhang, Shun’ichi Kuroda, Dale Carpenter, Ichiro Nishimura, Chia Soo, Rex Moats, Keisuke Iida, Eric Wisner, Fei-Ya Hu, Steve Miao, Steve Beanes, Catherine Dang, Heleni Vastardis, Michael Longaker, Katsuyuki Tanizawa, Norihiro Kanayama, Naoaki Saito, Kang Ting

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The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly
Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):651-658. https://doi.org/10.1172/JCI15528.
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The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

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Abstract

Research Article

Authors

Jennifer M. McCoy, Joan R. Wicks, Laurent P. Audoly

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Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
Min Li-Weber, … , Raoul Breitkreutz, Peter H. Krammer
Min Li-Weber, … , Raoul Breitkreutz, Peter H. Krammer
Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):681-690. https://doi.org/10.1172/JCI15073.
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Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

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Abstract

Research Article

Authors

Min Li-Weber, Markus A. Weigand, Marco Giaisi, Dorothee Süss, Monika K. Treiber, Sven Baumann, Elena Ritsou, Raoul Breitkreutz, Peter H. Krammer

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Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Alberto Auricchio, … , Roberto Calcedo, James M. Wilson
Published August 15, 2002
Citation Information: J Clin Invest. 2002;110(4):499-504. https://doi.org/10.1172/JCI15780.
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Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins

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Abstract

Research Article

Authors

Alberto Auricchio, Erin O’Connor, Daniel Weiner, Guang-Ping Gao, Markus Hildinger, Lili Wang, Roberto Calcedo, James M. Wilson

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A hop, exon skip, and a jump for muscular dystrophy
Quan Gao and colleagues developed an exon skipping strategy that generates a truncated, functional γ-sarcoglycan protein and improves defects in muscular dystrophy models…
Published October 12, 2015
Scientific Show StopperGenetics

A curve in the spine
Shunmoogum Patten and colleagues identify variants of POC5 that are associated with idiopathic scoliosis…
Published February 2, 2015
Scientific Show StopperGenetics
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