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Application of adult-derived human satellite cells
Muscle satellite cells are a rare regenerative population in adult skeletal muscle and have potential to repair damaged muscle tissue. In this episode, Simone Spuler and colleagues demonstrate that satellite cells can be successfully expanded from h...
Published August 26, 2014
Reversal of senescent phenotypes in human T cells
Age-related declines in immune function result in enhanced susceptibility to infection and decreased vaccine efficacy. While aged immune cells exhibit signs of cellular senescence, such as a reduced proliferative capacity, many maintain effector fun...
Published August 1, 2014
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid polypeptide (IAPP). Human IAPP is potentially toxic and has been shown to accumulate withi...
Published July 18, 2014
Evaluation of kisspeptin-54 for egg maturation
In virto fertilization (IVF) has helped millions of couples have children. While considered relatively safe, there are risks associated with this procedure. Among the more serious complications is the development of ovarian hyperstimulation syndrome...
Published July 18, 2014
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation of serine residues within the type II TGF-β receptor (TβRII) following activa...
Published July 1, 2014
MicroRNA-regulated network promotes pulmonary hypertension
Pulmonary hypertension is a complex disease that affects multiple vascular cell types, and mircoRNAs (miRNAs) have been implicated in the pathogenesis of this condition. In this episode, Stephen Chan discusses how his group used network theory to id...
Published June 24, 2014
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel Quiros-Gonzalez, and Liesbet Lieben discuss their use of a murine genetic model to e...
Published June 9, 2014
Epigenetic consequences of disturbed blood flow
The development of atherosclerotic plaques typically occurs in regions of arteries that have disturbed blood flow. While blood flow disturbances are known to alter endothelial gene expression and function, it is not clear how altered blood flow indu...
Published May 27, 2014
Examining RASA1 in vascular malformation
Capillary malformation-arteriovenous malformation (CM-AVM) results from inactivating mutations in the gene encoding RAS p21 protein activator (RASA1); however, RASA1 is expressed in multiple tissues, and it is not clear how RASA1 m...
Published May 16, 2014
Dendritic cell-dependent inhibition of malaria immunity
Induction of type I interferon (IFN) signaling is critical for host defense against most viruses; however, for some pathogens, including the parasite that causes malaria, induction of type I IFN-mediated pathways enhances host susceptibility to dise...
Published May 12, 2014
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American Society for Clinical Investigation
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