Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation of serine residues within the type II TGF-β receptor (TβRII) following activa...
Published July 1, 2014

Pulmonary hypertension is a complex disease that affects multiple vascular cell types, and mircoRNAs (miRNAs) have been implicated in the pathogenesis of this condition. In this episode, Stephen Chan discusses how his group used network theory to id...
Published June 24, 2014

The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes.  In this episode, Vijay Yadav, Isabel Quiros-Gonzalez, and Liesbet Lieben discuss their use of a murine genetic model to e...
Published June 9, 2014

The development of atherosclerotic plaques typically occurs in regions of arteries that have disturbed blood flow. While blood flow disturbances are known to alter endothelial gene expression and function, it is not clear how altered blood flow indu...
Published May 27, 2014

Capillary malformation-arteriovenous malformation (CM-AVM) results from inactivating mutations in the gene encoding RAS p21 protein activator (RASA1); however, RASA1 is expressed in multiple tissues, and it is not clear how RASA1 m...
Published May 16, 2014

Induction of type I interferon (IFN) signaling is critical for host defense against most viruses; however, for some pathogens, including the parasite that causes malaria, induction of type I IFN-mediated pathways enhances host susceptibility to dise...
Published May 12, 2014

Chronic itch is a common symptom and complaint for many dermatological patients. While some patients find relief with antihistamines, many do not, and the underlying pathways responsible for itch are poorly understood. In this episode, Martin Steinh...
Published May 8, 2014

Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved epitopes and display unique characteristics that suggest that their development may be limited by...
Published March 10, 2014

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly forms of cancer, primarily due to the resistance of PDAC tumors to current therapeutic strategies. Several lines of evidence suggest that ineffective delivery of chemotherapy agents t...
Published March 10, 2014

Familial Alzheimer's disease (FAD) is an early on-set, hereditary form of neurological disease with variable pathophysiology that is often associated with loss of cerebellar function and amyloid plaque formation. Diego Sepulveda-Falla and collea...
Published March 3, 2014