The cells that line the intestine, known as the intestinal mucosa, can become injured in disease states such as ulcerative colitis. To repair the injury, epithelial cells must migrate to the wound; however, the signals that drive this migration are unknown. Leoni et al. identified signaling pathways that mediate repair of the intestinal mucosa. The panels above show the colonic mucosa at 0, 1, and 6 days after biopsy-induced injury. In the upper row, the colonic mucosa was stained with antibodies against ANXA1 (green), F-actin (red), and nuclei (blue). Leoni and colleagues found that the protein AnxA1 promoted wound healing of the intestinal mucosa by driving epithelial cell migration.
Giovanna Leoni, Ashfaqul Alam, Philipp-Alexander Neumann, J. David Lambeth, Guangjie Cheng, James McCoy, Roland S. Hilgarth, Kousik Kundu, Niren Murthy, Dennis Kusters, Chris Reutelingsperger, Mauro Perretti, Charles A. Parkos, Andrew S. Neish, Asma Nusrat