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B4 androgen ablation: attacking the prostate cancer stem cell
Max S. Wicha
Max S. Wicha
Published January 25, 2013
Citation Information: J Clin Invest. 2013;123(2):563-565. https://doi.org/10.1172/JCI67460.
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Commentary

B4 androgen ablation: attacking the prostate cancer stem cell

Abstract

There is increasing evidence that prostate cancers in rodent models and in men contain a cellular subpopulation that displays stem cell properties. These prostate cancer stem cells (PCSCs) lack androgen receptor expression and are increased in castration-resistant disease. In this issue of the JCI, a study from Yoshioka et al. demonstrates that PCSCs are regulated by a pathway in which α6β4 integrin amplifies signaling through ErbB2 and c-Met receptors. Targeting this pathway provides a novel therapeutic strategy for hormone refractory prostate cancer.

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Max S. Wicha

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