Tregs expressing the transcription factor FOXP3 are critical for immune homeostasis. The costimulatory molecule CD28 is required for optimal activation and function of naive T cells; however, its role in Treg function has been difficult to dissect, as CD28 is required for thymic Treg development, and blockade of CD28-ligand interactions has confounding effects in
Ruan Zhang, Alexandria Huynh, Gregory Whitcher, JiHoon Chang, Jonathan S. Maltzman, Laurence A. Turka
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