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A unique role for Stat5 in recovery from acute anemia
Gregory D. Longmore
Gregory D. Longmore
Published March 1, 2006
Citation Information: J Clin Invest. 2006;116(3):626-628. https://doi.org/10.1172/JCI27988.
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Commentary

A unique role for Stat5 in recovery from acute anemia

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Abstract

The precise role of erythropoietin receptor–activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate a distinct role for Stat5 in the regulation of stress-induced erythropoiesis, such as during acute anemic states (see the related article beginning on page 683). A critical function for Stat5 is to promote cell survival, possibly through transcriptional induction of the antiapoptotic protein Bcl-x. In the present experimental system, erythropoietin-Stat5 signals did not induce Bcl-x expression but did induce oncostatin-M. Moreover, oncostatin-M was found to enhance survival of erythroid progenitors. This work differentiates between steady-state (or homeostatic) erythropoiesis and stress-induced erythropoiesis at the level of EpoR signaling.

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Gregory D. Longmore

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