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Navigating the Fas lane to improved cellular therapy for cancer
Madhav V. Dhodapkar
Madhav V. Dhodapkar
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Commentary

Navigating the Fas lane to improved cellular therapy for cancer

Abstract

Genetically engineered T cells have shown promising activity in the treatment of cancer. However, these cells are also potentially susceptible to immune-suppressive pathways in the tumor microenvironment that may limit their efficacy. In this issue of the JCI, Yamamoto et al. describe a new cellular engineering approach to prevent Fas-mediated inhibition of T cell function, which may be exploited to improve cellular therapy for cancer.

Authors

Madhav V. Dhodapkar

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