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Citation Information: J Clin Invest. 1987;79(4):1281-1284. https://doi.org/10.1172/JCI112949.
Abstract
Early thymus-derived lymphocytes bearing the T gamma gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have T gamma gene rearrangement and T gamma transcripts in absence of T alpha or T beta rearrangement or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative T gamma protein.
Authors
R González-Sarmiento, T W LeBien, J G Bradley, J M Greenberg, J G Seidman, S Ang, J H Kersey
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