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In Vivo Effects of Protease Inhibitors on Chickens with Hereditary Muscular Dystrophy
Michael S. Hudecki, … , Catherine M. Pollina, Reid R. Heffner
Michael S. Hudecki, … , Catherine M. Pollina, Reid R. Heffner
Published April 1, 1981
Citation Information: J Clin Invest. 1981;67(4):969-974. https://doi.org/10.1172/JCI110147.
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Research Article

In Vivo Effects of Protease Inhibitors on Chickens with Hereditary Muscular Dystrophy

Abstract

Beginning on day 4 ex ovo, and every 3 d thereafter, genetically dystrophic Line 413 chickens were given intraperitoneal injections (4 mg/kg body wt) of a protease inhibitor, leupeptin, pepstatin, or antipain. Experimental chickens received protease inhibitors dissolved in a water:ethanol:dimethyl sulfoxide solution (50:40:10, vol:vol:vol). Control untreated animals received diluent injections.

Authors

Michael S. Hudecki, Catherine M. Pollina, Reid R. Heffner

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