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Citation Information: J Clin Invest. 1981;67(3):878-884. https://doi.org/10.1172/JCI110105.
Abstract
By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.
Authors
S H Orkin, S C Goff, D G Nathan
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