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Effects of Hepatectomy, Nephrectomy, and Nephrectomy/Uremia on the Metabolism of Parathyroid Hormone in the Rat
Gino V. Segre, … , Anne Hultman, John T. Potts Jr.
Gino V. Segre, … , Anne Hultman, John T. Potts Jr.
Published February 1, 1981
Citation Information: J Clin Invest. 1981;67(2):439-448. https://doi.org/10.1172/JCI110052.
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Research Article

Effects of Hepatectomy, Nephrectomy, and Nephrectomy/Uremia on the Metabolism of Parathyroid Hormone in the Rat

Abstract

Reports from several laboratories, showing extensive hepatic extraction of circulating parathyroid hormone, led us to examine the effect of near-total hepatectomy on the metabolism of the hormone to circulating fragments, and on its clearance from plasma. The rate of disappearance of 125I-labeled and unlabeled bovine parathyroid hormone from plasma, and the appearance, disappearance, and chemical and immunochemical characteristics of circulating fragments were examined by gel filtration and either sequence-specific radioimmunoassays or sequence analysis using the Edman reaction. Results from awake rats subjected to near-total hepatectomy were compared with those found in sham-treated, nephrectomized, and short-term uremic rats (studied 2 d after nephrectomy). When compared with the sham-treated group, all other groups clear 125I-labeled hormone more slowly; after hepatectomy, however, the clearance rate is most strikingly decreased.

Authors

Gino V. Segre, Pierre D'Amour, Anne Hultman, John T. Potts Jr.

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