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Citation Information: J Clin Invest. 1980;65(2):413-421. https://doi.org/10.1172/JCI109684.
Abstract
Plasma from individuals with high molecular weight (HMW) kininogen deficiency has been reported to be deficient in prekallikrein as measured by radial immunodiffusion, prekallikrein coagulant activity, and/or kaolin-activated arginine esterase activity. The discovery that prekallikrein and HMW kininogen circulate as a complex in plasma led us to reevaluate the antigenic and functional properties of prekallikrein in HMW kininogen-deficient plasma as well as in normal plasma.
Authors
Cheryl F. Scott, Robert W. Colman
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