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Function and Immunochemistry of Prekallikrein-High Molecular Weight Kininogen Complex in Plasma
Cheryl F. Scott, Robert W. Colman
Cheryl F. Scott, Robert W. Colman
Published February 1, 1980
Citation Information: J Clin Invest. 1980;65(2):413-421. https://doi.org/10.1172/JCI109684.
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Research Article

Function and Immunochemistry of Prekallikrein-High Molecular Weight Kininogen Complex in Plasma

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Abstract

Plasma from individuals with high molecular weight (HMW) kininogen deficiency has been reported to be deficient in prekallikrein as measured by radial immunodiffusion, prekallikrein coagulant activity, and/or kaolin-activated arginine esterase activity. The discovery that prekallikrein and HMW kininogen circulate as a complex in plasma led us to reevaluate the antigenic and functional properties of prekallikrein in HMW kininogen-deficient plasma as well as in normal plasma.

Authors

Cheryl F. Scott, Robert W. Colman

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