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Citation Information: J Clin Invest. 1980;65(2):329-337. https://doi.org/10.1172/JCI109676.
Abstract
Carbenicillin or penicillin G administered in large doses can cause a bleeding diathesis as a result of platelet dysfunction. These antibiotics also inhibit platelet aggregation in vitro, although several-fold larger concentrations of drug are required to demonstrate this effect. We wondered whether these antibiotics might impair platelet function by interfering with the initial step of platelet activation: the binding of agonists to their specific receptors on the platelet surface.
Authors
Sanford J. Shattil, Joel S. Bennett, Margaret McDonough, Judy Turnbull
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