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Joseph R. Bloomer
Citation Information: J Clin Invest. 1980;65(2):321-328. https://doi.org/10.1172/JCI109675.
Joseph R. Bloomer
Published February 1, 1980
Citation Information: J Clin Invest. 1980;65(2):321-328. https://doi.org/10.1172/JCI109675.
Abstract
Heme synthase (ferrochelatase) activity, as determined by the chelation of ferrous iron to protoporphyrin or deuteroporphyrin, is reduced to 10-25% of normal in tissues of patients with protoporphyria. With cultured skin fibroblasts from seven patients with protoporphyria and six normal individuals, the present studies examined the enzymatic defect.
Authors
Joseph R. Bloomer
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