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Diurnal Variation in the Responsiveness of Human Subjects to Human Growth Hormone
Daniel Rudman, … , Joseph H. Patterson, Donna L. Gibbas
Daniel Rudman, … , Joseph H. Patterson, Donna L. Gibbas
Published April 1, 1973
Citation Information: J Clin Invest. 1973;52(4):912-918. https://doi.org/10.1172/JCI107256.
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Research Article

Diurnal Variation in the Responsiveness of Human Subjects to Human Growth Hormone

Abstract

The objective of this study was to compare the responsiveness of human subjects to the anabolic effects of human growth hormone (HGH) administered at 8 a.m. or at 11 p.m. Three doses of HGH were used: A, 0.0168 U/kg body weight (BW)3/4 per day; B, 0.0532 U/kg BW3/4 per day; C, 0.168 U/kg BW3/4 per day. The effect of each dose on daily balances of N, P, Na, and K and on BW was measured. The subjects were of two groups: (a) seven GH-deficient children, of whom three were deficient in ACTH; and (b) three patients with limb-girdle dystrophy. ACTH-deficient patients in group (a) received exogenous cortisol at 7 a.m. In all 10 subjects, the anabolic effects of dose C, and sometimes of B and A, administered at 11 p.m. were significantly (P < 0.05) greater than when administered at 8 a.m. In these experiments plasma cortisol concentration averaged 3 times greater at 8 a.m. than at 11 p.m.

Authors

Daniel Rudman, David Freides, Joseph H. Patterson, Donna L. Gibbas

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