Submit a comment
Citation Information: J Clin Invest. 1972;51(9):2310-2314. https://doi.org/10.1172/JCI107041.
Abstract
The effects of CCl4 on albumin synthesis were studied employing the isolated perfused liver. Carbonate-14C was used to measure newly synthesized albumin. 2.5 ml of CCl4 was administered by stomach tube 2 hr before perfusion. Albumin synthesis decreased from 36 to 5 mg following the ingestion of CCl4. Preperfusing the livers for 1 hr before measuring albumin synthesis resulted in an increase to 12 mg, and the addition of tryptophan to a final concentration of 10 mM resulted in a further increase to 19 mg. Cortisone did not protect against the toxic effects of CCl4 when administered to the donor rabbits. Fasting resulted in an increased sensitivity to CCl4 and an antioxidant was not effective in protecting against the toxic manifestations of CCl4.
Authors
Marcus A. Rothschild, Murray Oratz, Sidney S. Schreiber
Guidelines
The Editorial Board will only consider comments that are deemed relevant and of interest to readers. The Journal will not post data that have not been subjected to peer review; or a comment that is essentially a reiteration of another comment.
- Comments appear on the Journal’s website and are linked from the original article’s web page.
- Authors are notified by email if their comments are posted.
- The Journal reserves the right to edit comments for length and clarity.
- No appeals will be considered.
- Comments are not indexed in PubMed.
Specific requirements
- Maximum length, 400 words
- Entered as plain text or HTML
- Author’s name and email address, to be posted with the comment
- Declaration of all potential conflicts of interest (even if these are not ultimately posted); see the Journal’s conflict-of-interest policy
- Comments may not include figures
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)