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Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection
Robert I. Lehrer, Martin J. Cline
Robert I. Lehrer, Martin J. Cline
Published August 1, 1969
Citation Information: J Clin Invest. 1969;48(8):1478-1488. https://doi.org/10.1172/JCI106114.
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Research Article

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

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Abstract

The neutrophils and monocytes of a patient with disseminated candidiasis were found to lack detectable levels of the lysosomal enzyme myeloperoxidase (MPO), although they had normal levels of other granule-associated enzymes. Leukocytes from one of the patient's sisters also lacked detectable MPO; leukocytes from his four sons contained approximately one-third of mean normal peroxidase levels. Neither the patient nor his affected relatives had experienced frequent or unusual bacterial infections.

Authors

Robert I. Lehrer, Martin J. Cline

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