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Citation Information: J Clin Invest. 1969;48(8):1408-1412. https://doi.org/10.1172/JCI106106.
Abstract
In studies employing rat renal cortical slices, the addition of adenosine 3′,5′-monophosphate (cyclic AMP) to the incubation medium caused an increase in production of glucose from glutamine, glutamate, α-ketoglutarate, fumarate, malate, and oxalacetate, but not from glycerol and fructose. These observations suggest that cyclic AMP accelerates a rate-limiting gluconeogenic reaction between oxalacetate and the triose phosphates. The addition to the medium of parathyroid hormone, which is known to increase renal cortical cyclic AMP, also stimulated glucose production from glutamine.
Authors
Anthony S. Pagliara, A. David Goodman
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