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Citation Information: J Clin Invest. 1968;47(1):118-126. https://doi.org/10.1172/JCI105702.
Abstract
Magnesium-deficient rats develop significant hypercalcemia, hypophosphatemia, and hyperphosphaturia. These changes suggest a state of hyperparathyroidism. This study examines the regulation of parathyroid gland activity in magnesium-deficient rats. Magnesium deficiency was induced in intact and chronically parathyroidectomized animals by feeding them a diet free of this cation. Control animals were pair fed and treated identically except for the inclusion of magnesium in their gavage solution.
Authors
H. J. Gitelman, S. Kukolj, L. G. Welt
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