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Citation Information: J Clin Invest. 1967;46(9):1451-1460. https://doi.org/10.1172/JCI105637.
Abstract
Replacement of dietary triglycerides containing long-chain fatty acids (LCFA) by triglycerides containing medium-chain fatty acids (MCFA) markedly reduced the capacity of alcohol to produce fatty liver in rats. After 24 days of ethanol and MCFA, the increase in hepatic triglycerides was only 3 times that of controls, whereas an 8-fold rise was observed after ethanol and LCFA. The triglyceride fatty acids that accumulated in the liver after feeding of ethanol with MCFA contained only a small percentage of the MCFA; their composition also differed strikingly from that of adipose lipids.
Authors
Charles S. Lieber, André Lefèvre, Norton Spritz, Lawrence Feinman, Leonore M. DeCarli
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