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Studies on the Intracerebral Toxicity of Ammonia
Steven Schenker, … , Edward Brophy, Michael S. Lewis
Steven Schenker, … , Edward Brophy, Michael S. Lewis
Published May 1, 1967
Citation Information: J Clin Invest. 1967;46(5):838-848. https://doi.org/10.1172/JCI105583.
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Research Article

Studies on the Intracerebral Toxicity of Ammonia

Abstract

Interference with cerebral energy metabolism due to excess ammonia has been postulated as a cause of hepatic encephalopathy. Furthermore, consideration of the neurologic basis of such features of hepatic encephalopathy as asterixis, decerebrate rigidity, hyperpnea, and coma suggests a malfunction of structures in the base of the brain and their cortical connections.

Authors

Steven Schenker, David W. McCandless, Edward Brophy, Michael S. Lewis

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