Submit a comment

Atrial Fibrillation in the Intact Unanesthetized Dog: Hemodynamic Effects during Rest, Exercise, and Beta-Adrenergic Blockade
Richard H. Martin, … , Samuel T. Lim, Robert L. Van Citters
Richard H. Martin, … , Samuel T. Lim, Robert L. Van Citters
Published February 1, 1967
Citation Information: J Clin Invest. 1967;46(2):205-216. https://doi.org/10.1172/JCI105523.
View: Text | PDF
Research Article

Atrial Fibrillation in the Intact Unanesthetized Dog: Hemodynamic Effects during Rest, Exercise, and Beta-Adrenergic Blockade

Abstract

The effects of atrial fibrillation were studied in 12 healthy unanesthetized dogs, 9 to 49 days after surgical implantation of transducers for measurement of aortic flow and left ventricular diameter. Atrial fibrillation and pacing at comparable ventricular rates were induced by electrical stimulation of the right atrial appendage, and their effects were compared with observations made during sinus rhythm in each dog. At rest, cardiac output and mean arterial pressure were not significantly different during sinus rhythm, atrial fibrillation, and atrial pacing. After beta-adrenergic blockade with propranolol, cardiac output during fibrillation was significantly less than that during pacing at comparable ventricular rates. Arterial pressure was not detectably altered. During moderately severe treadmill exercise by six dogs, cardiac output fell significantly upon induction of fibrillation. After pentobarbital anesthesia fibrillation caused decrements in cardiac output and arterial pressure that were accentuated after thoracotomy.

Authors

Richard H. Martin, Samuel T. Lim, Robert L. Van Citters

×

Guidelines

The Editorial Board will only consider comments that are deemed relevant and of interest to readers. The Journal will not post data that have not been subjected to peer review; or a comment that is essentially a reiteration of another comment.

  • Comments appear on the Journal’s website and are linked from the original article’s web page.
  • Authors are notified by email if their comments are posted.
  • The Journal reserves the right to edit comments for length and clarity.
  • No appeals will be considered.
  • Comments are not indexed in PubMed.

Specific requirements

  • Maximum length, 400 words
  • Entered as plain text or HTML
  • Author’s name and email address, to be posted with the comment
  • Declaration of all potential conflicts of interest (even if these are not ultimately posted); see the Journal’s conflict-of-interest policy
  • Comments may not include figures
This field is required
This field is required
This field is required
This field is required
This field is required
This field is required