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Usage Information

Strategies targeting cellular senescence
Yossi Ovadya, Valery Krizhanovsky
Yossi Ovadya, Valery Krizhanovsky
Published April 2, 2018
Citation Information: J Clin Invest. 2018;128(4):1247-1254. https://doi.org/10.1172/JCI95149.
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Review Series

Strategies targeting cellular senescence

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Abstract

Cellular senescence is a physiological phenomenon that has both beneficial and detrimental consequences. Senescence limits tumorigenesis and tissue damage throughout the lifetime. However, at the late stages of life, senescent cells increasingly accumulate in tissues and might also contribute to the development of various age-related pathologies. Recent studies have revealed the molecular pathways that preserve the viability of senescent cells and the ones regulating their immune surveillance. These studies provide essential initial insights for the development of novel therapeutic strategies for targeting senescent cells. At the same time they stress the need to understand the limitations of the existing strategies, their efficacy and safety, and the possible deleterious consequences of senescent cell elimination. Here we discuss the existing strategies for targeting senescent cells and upcoming challenges in translating these strategies into safe and efficient therapies. Successful translation of these strategies could have implications for treating a variety of diseases at old age and could potentially reshape our view of health management during aging.

Authors

Yossi Ovadya, Valery Krizhanovsky

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 1,625 436
PDF 205 70
Figure 164 2
Table 58 0
Citation downloads 125 0
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Total Views 2,685
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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