Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA
G. Paolo Rizzardi, Rob J. De Boer, Shelley Hoover, Giuseppe Tambussi, Aude Chapuis, Nermin Halkic, Pierre-Alexandre Bart, Veronica Miller, Schlomo Staszewski, Daan W. Notermans, Luc Perrin, Cecil H. Fox, Joep M.A. Lange, Adriano Lazzarin, Giuseppe Pantaleo
G. Paolo Rizzardi, Rob J. De Boer, Shelley Hoover, Giuseppe Tambussi, Aude Chapuis, Nermin Halkic, Pierre-Alexandre Bart, Veronica Miller, Schlomo Staszewski, Daan W. Notermans, Luc Perrin, Cecil H. Fox, Joep M.A. Lange, Adriano Lazzarin, Giuseppe Pantaleo
View: Text | PDF
Article

Predicting the duration of antiviral treatment needed to suppress plasma HIV-1 RNA

Abstract

Effective therapeutic interventions and clinical care of adults infected with HIV-1 require an understanding of factors that influence time of response to antiretroviral therapy. We have studied a cohort of 118 HIV-1–infected subjects naive to antiretroviral therapy and have correlated the time of response to treatment with a series of virological and immunological measures, including levels of viral load in blood and lymph node, percent of CD4 T cells in lymph nodes, and CD4 T-cell count in blood at study entry. Suppression of viremia below the limit of detection, 50 HIV-1 RNA copies/mL of plasma, served as a benchmark for a successful virological response. We employed these correlations to predict the length of treatment required to attain a virological response in each patient. Baseline plasma viremia emerged as the factor most tightly correlated with the duration of treatment required, allowing us to estimate the required time as a function of this one measure.

Authors

G. Paolo Rizzardi, Rob J. De Boer, Shelley Hoover, Giuseppe Tambussi, Aude Chapuis, Nermin Halkic, Pierre-Alexandre Bart, Veronica Miller, Schlomo Staszewski, Daan W. Notermans, Luc Perrin, Cecil H. Fox, Joep M.A. Lange, Adriano Lazzarin, Giuseppe Pantaleo

×

Figure 3

Options: View larger image (or click on image) Download as PowerPoint
Estimated time to suppress plasma HIV-1 RNA below 50 copies/mL based upo...
Estimated time to suppress plasma HIV-1 RNA below 50 copies/mL based upon varying levels of baseline plasma HIV-1 RNA. The estimated required number of days (thick continuous line) with 95% confidence limits (thin continuous lines) are shown. To use this prediction for patients who have a certain baseline value, the population SEs for several baseline values were calculated; the 95% confidence level is t multiplied by the SE, where t = 2 is the Student’s t value for P < 0.05 and df = 116. Time is expressed in number of days, and plasma HIV-1 RNA levels are expressed in log10 copies per milliliter.