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Usage Information

Role of innate and adaptive immunity in obesity-associated metabolic disease
Tracey McLaughlin, … , Lei Shen, Edgar Engleman
Tracey McLaughlin, … , Lei Shen, Edgar Engleman
Published January 3, 2017
Citation Information: J Clin Invest. 2017;127(1):5-13. https://doi.org/10.1172/JCI88876.
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Review Series

Role of innate and adaptive immunity in obesity-associated metabolic disease

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Abstract

Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR). Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process. Thus, M1 macrophages, IFN-γ–secreting Th1 cells, CD8+ T cells, and B cells promote IR, in part through secretion of proinflammatory cytokines. Conversely, eosinophils, Th2 T cells, type 2 innate lymphoid cells, and possibly Foxp3+ Tregs protect against IR through local control of inflammation.

Authors

Tracey McLaughlin, Shelley E. Ackerman, Lei Shen, Edgar Engleman

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Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 2,156 488
PDF 210 90
Figure 153 0
Table 58 0
Citation downloads 93 0
Totals 2,670 578
Total Views 3,248
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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