Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis
Ana L. Mora,1,2 Marta Bueno,1,2 and Mauricio Rojas1,2,3
1Vascular Medicine Institute, Department of Medicine,
2Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, and
3The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Ana L. Mora, Vascular Medicine Institute, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, E-1246 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA. Phone: 412.624.2291; E-mail: anamora@pitt.edu.
Find articles by Mora, A. in: JCI | PubMed | Google Scholar
1Vascular Medicine Institute, Department of Medicine,
2Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, and
3The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Ana L. Mora, Vascular Medicine Institute, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, E-1246 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA. Phone: 412.624.2291; E-mail: anamora@pitt.edu.
Find articles by Bueno, M. in: JCI | PubMed | Google Scholar
1Vascular Medicine Institute, Department of Medicine,
2Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, and
3The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Address correspondence to: Ana L. Mora, Vascular Medicine Institute, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, E-1246 BST, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA. Phone: 412.624.2291; E-mail: anamora@pitt.edu.
Find articles by Rojas, M. in: JCI | PubMed | Google Scholar
First published February 1, 2017 - More info
J Clin Invest. 2017;127(2):405–414. doi:10.1172/JCI87440.
Copyright © 2017, American Society for Clinical Investigation
Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality that is characterized by abnormal scarring of the lung parenchyma. There has been a recent attempt to define the age-associated changes predisposing individuals to develop IPF. Age-related perturbations that are increasingly found in epithelial cells and fibroblasts from IPF lungs compared with age-matched cells from normal lungs include defective autophagy, telomere attrition, altered proteostasis, and cell senescence. These divergent processes seem to converge in mitochondrial dysfunction and metabolic distress, which potentiate maladaptation to stress and susceptibility to age-related diseases such as IPF. Therapeutic approaches that target aging processes may be beneficial for halting the progression of disease and improving quality of life in IPF patients.
- Purchase this article
- $10
- Purchasing this article will give you full access for the calendar year.
- Purchase Site Pass
- $25
- This will give you access to every article on the site for 24 hours.
- Online subscription
- $95
- Individual online subscriptions give you full online access for the calendar year.
- Print subscription
- $795
- Individual print subscriptions give you the print journal and full online access for the year.
- JCI This Month subscription
- $125
- JCI This Month is a 16- to 20-page overview of the articles published each month
- Subscribing to JCI This Month also gives subscribers full online access for the calendar year.
- *Price outside U.S. and Canada: $225.
Copyright © 2017 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)