Substantial ischemia-reperfusion injury (IRI) to the transplanted kidney occurs in 30% to 50% of transplantation patients who receive the organ from a deceased donor. IRI usually manifests as delayed graft function (DGF) and, in severe cases, results in primary nonfunction. Previous studies, primarily experimental, have demonstrated sex-specific susceptibility to IRI in kidney and other organs. In this issue of the
Sanjeev Noel, Niraj M. Desai, Abdel Rahim A. Hamad, Hamid Rabb
Sex affects the susceptibility and pathogenesis of IRI in a single transplanted kidney.