Adil I. Daud, Kimberly Loo, Mariela L. Pauli, Robert Sanchez-Rodriguez, Priscila Munoz Sandoval, Keyon Taravati, Katy Tsai, Adi Nosrati, Lorenzo Nardo, Michael D. Alvarado, Alain P. Algazi, Miguel H. Pampaloni, Iryna V. Lobach, Jimmy Hwang, Robert H. Pierce, Iris K. Gratz, Matthew F. Krummel, Michael D. Rosenblum
Clinical characteristics and CTL profiles of patients with metastatic melanoma who responded or did not respond to anti–PD-1 therapy.
Histogram showing flow cytometric quantification of the percentages of CTLA4hiPD-1hi tumor-infiltrating T cells in the CD8+ CTL gate versus characteristics of individual patients. Responders included patients with tumor target lesions that met RECIST 1.1 criteria for a CR (>99% reduction in the target lesions) or a PR (≥30% reduction in target lesions). Nonresponders included patients with tumor target lesions that met RECIST 1.1 criteria for progressive (≥20% increase in the target lesions) or stable disease (<30% reduction or <20% increase in tumor target lesions).