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Usage Information

New perspectives on the hepatitis B virus life cycle in the human liver
Peter A. Revill, Stephen A. Locarnini
Peter A. Revill, Stephen A. Locarnini
Published February 22, 2016
Citation Information: J Clin Invest. 2016;126(3):833-836. https://doi.org/10.1172/JCI86650.
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Commentary

New perspectives on the hepatitis B virus life cycle in the human liver

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Abstract

The central role of the transcriptional template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to study in patients with chronic hepatitis B (CHB) infection. In this issue of the JCI, Zhang and colleagues reveal a mosaic distribution of viral antigens and nucleic acids and a mismatch between HBV cccDNA, RNA, and expression of the hepatitis B surface antigen (HBsAg). These unusual patterns varied over the natural history of CHB, prompting the authors to propose a new three-stage model of the HBV life cycle at the single-cell level.

Authors

Peter A. Revill, Stephen A. Locarnini

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 751 153
PDF 125 29
Figure 525 1
Citation downloads 67 0
Totals 1,468 183
Total Views 1,651
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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