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Usage Information

New perspectives on the hepatitis B virus life cycle in the human liver
Peter A. Revill, Stephen A. Locarnini
Peter A. Revill, Stephen A. Locarnini
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Commentary

New perspectives on the hepatitis B virus life cycle in the human liver

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Abstract

The central role of the transcriptional template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to study in patients with chronic hepatitis B (CHB) infection. In this issue of the JCI, Zhang and colleagues reveal a mosaic distribution of viral antigens and nucleic acids and a mismatch between HBV cccDNA, RNA, and expression of the hepatitis B surface antigen (HBsAg). These unusual patterns varied over the natural history of CHB, prompting the authors to propose a new three-stage model of the HBV life cycle at the single-cell level.

Authors

Peter A. Revill, Stephen A. Locarnini

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Usage data is cumulative from December 2024 through December 2025.

Usage JCI PMC
Text version 964 208
PDF 136 34
Figure 458 1
Citation downloads 56 0
Totals 1,614 243
Total Views 1,857
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ISSN: 0021-9738 (print), 1558-8238 (online)

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