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Usage Information

Transplant tolerance: a new role for IL-34
James I. Kim, Laurence A. Turka
James I. Kim, Laurence A. Turka
Published September 21, 2015
Citation Information: J Clin Invest. 2015;125(10):3751-3753. https://doi.org/10.1172/JCI84010.
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Commentary

Transplant tolerance: a new role for IL-34

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Abstract

Immune-suppressive cell populations, including Tregs and suppressor monocytes, have been implicated in long-term survival of allografts in both human transplant recipients and animal models. The factors that drive differentiation and function of these cell populations are not completely understood. In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft tolerance in a rat model of heart transplantation. Their data support a model in which IL-34 production by Tregs promotes a population of suppressive macrophages that in turn promote Treg differentiation. The results of this study support further exploration of the immunosuppressive properties of IL-34.

Authors

James I. Kim, Laurence A. Turka

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 252 18
PDF 54 31
Figure 55 1
Citation downloads 62 0
Totals 423 50
Total Views 473
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