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Hungry irony
Nancy C. Andrews
Nancy C. Andrews
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Commentary

Hungry irony

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Abstract

Iron-deficient individuals experience a loss of appetite that can be restored with iron supplementation. It has been proposed that iron influences the satiety hormone leptin; however, a direct link between iron and leptin has remained elusive. In this issue of the JCI, Gao and colleagues demonstrate an inverse relationship between adipocyte iron and leptin that is mediated by iron-dependent activation of cAMP-responsive element binding protein (CREB), the transcription factor that represses leptin transcription. Together, the results of this study provide a mechanistic connection between dietary iron and the appetite-regulating hormone leptin.

Authors

Nancy C. Andrews

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
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PDF 219 25
Figure 179 6
Citation downloads 155 0
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Total Views 4,400

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ISSN: 0021-9738 (print), 1558-8238 (online)

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