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Usage Information

Versatile roles of extracellular vesicles in cancer
Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya
Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya
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Review Series

Versatile roles of extracellular vesicles in cancer

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Abstract

Numerous studies have shown that non–cell-autonomous regulation of cancer cells is an important aspect of tumorigenesis. Cancer cells need to communicate with stromal cells by humoral factors such as VEGF, FGFs, and Wnt in order to survive. Recently, extracellular vesicles (EVs) have also been shown to be involved in cell-cell communication between cancer cells and the surrounding microenvironment and to be important for the development of cancer. In addition, these EVs contain small noncoding RNAs, including microRNAs (miRNAs), which contribute to the malignancy of cancer cells. Here, we provide an overview of current research on EVs, especially miRNAs in EVs. We also propose strategies to treat cancers by targeting EVs around cancer cells.

Authors

Nobuyoshi Kosaka, Yusuke Yoshioka, Yu Fujita, Takahiro Ochiya

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Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 1,998 68
PDF 282 34
Figure 515 4
Table 136 0
Citation downloads 170 0
Totals 3,101 106
Total Views 3,207
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