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Loss of P2Y14 results in an arresting response to hematological stress
Brian S. Garrison, Derrick J. Rossi
Brian S. Garrison, Derrick J. Rossi
Published June 17, 2014
Citation Information: J Clin Invest. 2014;124(7):2846-2848. https://doi.org/10.1172/JCI76626.
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Commentary

Loss of P2Y14 results in an arresting response to hematological stress

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Abstract

The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem cells detect stress and initiate appropriate responses are poorly understood. In this issue of the JCI, Cho and Yusuf et al. demonstrate that the purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative response.

Authors

Brian S. Garrison, Derrick J. Rossi

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