Loss of P2Y14 results in an arresting response to hematological stress
Brian S. Garrison, Derrick J. Rossi
Brian S. Garrison, Derrick J. Rossi
Published June 17, 2014
Citation Information: J Clin Invest. 2014;124(7):2846-2848. https://doi.org/10.1172/JCI76626.
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Commentary

Loss of P2Y14 results in an arresting response to hematological stress

Abstract

The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem cells detect stress and initiate appropriate responses are poorly understood. In this issue of the JCI, Cho and Yusuf et al. demonstrate that the purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative response.

Authors

Brian S. Garrison, Derrick J. Rossi

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Figure 1

HSPCs lacking P2Y14 have reduced functionality.

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HSPCs lacking P2Y14 have reduced functionality. Competitive transplantat...
Competitive transplantation of WT and P2Y14-deficient HSPCs into an irradiated animal results in equal repopulation of the hematopoietic environment. Following blood reconstitution, P2y14–/– HSPCs exhibit a competitive disadvantage if mice are exposed to additional hematological stress, such as irradiation or serial transplantation. Furthermore, in response to stress, P2Y14-deficient HSPCs show several markers of senescence, including increased ROS, p38 MAPK, p16INK4A, and SA–β-gal.