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Usage Information

Emerging roles for enteric glia in gastrointestinal disorders
Keith A. Sharkey
Keith A. Sharkey
Published February 17, 2015
Citation Information: J Clin Invest. 2015;125(3):918-925. https://doi.org/10.1172/JCI76303.
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Review Series

Emerging roles for enteric glia in gastrointestinal disorders

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Abstract

Enteric glia are important components of the enteric nervous system (ENS) and also form an extensive network in the mucosa of the gastrointestinal (GI) tract. Initially regarded as passive support cells, it is now clear that they are actively involved as cellular integrators in the control of motility and epithelial barrier function. Enteric glia form a cellular and molecular bridge between enteric nerves, enteroendocrine cells, immune cells, and epithelial cells, depending on their location. This Review highlights the role of enteric glia in GI motility disorders and in barrier and defense functions of the gut, notably in states of inflammation. It also discusses the involvement of enteric glia in neurological diseases that involve the GI tract.

Authors

Keith A. Sharkey

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,280 207
PDF 99 45
Figure 191 5
Table 62 0
Citation downloads 68 0
Totals 1,700 257
Total Views 1,957
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