Cetuximab is a murine-human chimeric IgG1 mAb directed against the EGFR that is approved for use in patients with colorectal and head and neck carcinomas. While some patients benefit greatly from cetuximab, many do not; therefore, strategies to increase the efficacy of this drug are of great clinical interest. In this issue of the
Julie E. Bauman, Jennifer R. Grandis
Intracellular and extracellular approaches to increasing cetuximab efficacy.