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Repurposing staples for viruses: applying peptide design to RSV prophylaxis
Sarah P. Katen, Terence S. Dermody
Sarah P. Katen, Terence S. Dermody
Published April 17, 2014
Citation Information: J Clin Invest. 2014;124(5):1889-1891. https://doi.org/10.1172/JCI75797.
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Commentary

Repurposing staples for viruses: applying peptide design to RSV prophylaxis

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Abstract

Respiratory syncytial virus (RSV) is responsible for lower respiratory tract infections and annually results in 200,000 deaths worldwide. Despite the burden of RSV-associated disease, treatments and preventative measures are limited. In this issue of JCI, Bird and colleagues describe their work using a peptide stapling technique that allowed synthesis of a stable peptide mimic of a portion of the RSV fusion protein. Pretreatment of cells with the stable peptide effectively blocked virus entry. When introduced into mice prior to RSV exposure, the peptide produced a substantial prophylactic effect. This work provides a new way forward in RSV prevention.

Authors

Sarah P. Katen, Terence S. Dermody

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