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Usage Information

Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch
Julienne L. Carstens, Sara Lovisa, Raghu Kalluri
Julienne L. Carstens, Sara Lovisa, Raghu Kalluri
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Commentary

Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch

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Abstract

The metastatic spread of tumor epithelial cells accounts for over 90% of cancer-specific mortality; however, the molecular mechanisms that govern tumor spread and distant recolonization remain unclear. In this issue of JCI, Rokavec and colleagues shine light on this murky aspect of tumor biology by focusing through the lens of microenvironmental contributions, namely inflammation, as driving signals that set off a delicate, intracellular feedback loop among cytokine receptors, transcription factors and miRNAs. This study provides in vivo evidence and identifies molecular players behind the elusive switch that drives the epithelial-to-mesenchymal transition and the mesenchymal-to-epithelial transition.

Authors

Julienne L. Carstens, Sara Lovisa, Raghu Kalluri

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 665 15
PDF 239 1
Figure 205 2
Citation downloads 178 0
Totals 1,287 18
Total Views 1,305
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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