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Usage Information

The lymphatic vasculature revisited
Dontscho Kerjaschki
Dontscho Kerjaschki
Published March 3, 2014
Citation Information: J Clin Invest. 2014;124(3):874-877. https://doi.org/10.1172/JCI74854.
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Review Series

The lymphatic vasculature revisited

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Abstract

Lymphatic vessels constitute a ubiquitous countercurrent system to the blood vasculature that returns interstitial fluid, salts, small molecules, resorbed fat, and cells to the bloodstream. They serve as conduits to lymph nodes and are essential for multiple physiologic activities. However, they are also hijacked by cancer cells to establish initial lymph node metastases, as well as by infectious agents and parasites. Despite these obvious important functions in human pathologies, a more detailed understanding of the molecular mechanisms involved in the regulation of the lymphatic vasculature has trailed that of the blood vasculature for many years, mainly because critical specific characteristics of lymphatic endothelial cells were discovered only recently. In this Review series, several major aspects of the active and passive involvement of the lymphatic vasculature in human disease and physiology are presented, with a focus on translational findings.

Authors

Dontscho Kerjaschki

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 745 76
PDF 98 44
Figure 196 0
Citation downloads 80 0
Totals 1,119 120
Total Views 1,239
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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