Published November 1, 2013 - More info
Progressive osseous heteroplasia (POH) is a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous inactivating germline mutations in the paternal allele of the
Dana M. Cairns, Robert J. Pignolo, Tomoya Uchimura, Tracy A. Brennan, Carter M. Lindborg, Meiqi Xu, Frederick S. Kaplan, Eileen M. Shore, Li Zeng
Original citation: J. Clin. Invest. 2013;123(8):3624–3633. doi:10.1172/JCI69746.
Citation for this addendum: J. Clin. Invest. 2013;123(11):4981. doi:10.1172/JCI73496.
Since the publication of the article, the authors have learned that a prior publication reported on patient 5 in an independent research study. Following standard procedures to maintain confidentiality, the authors were unaware that the patient was a participant in a separate study at the time the article was prepared; they became aware when they were contacted by the authors of the prior publication. In the interest of providing more complete information regarding reported subjects, they wish to add a note of this report in Methods. The correct additional sentence is below.
Patient 5 was evaluated for this study at the University of Pennsylvania Orthopaedic Surgery Outpatient Clinic; this individual was also previously described as patient 1 in a prior publication (51).
51. Lebrun M, et al. Progressive osseous heteroplasia: a model for the imprinting effects of GNAS inactivating mutations in humans. J Clin Endocrinol Metab. 2010;95(6):3028–3038.
The authors anticipate that this information will provide a more complete view of the patient and disease to the scientific and medical community.