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Usage Information

Emerging roles of lymphatic endothelium in regulating adaptive immunity
Catherine M. Card, … , Shann S. Yu, Melody A. Swartz
Catherine M. Card, … , Shann S. Yu, Melody A. Swartz
Published March 3, 2014
Citation Information: J Clin Invest. 2014;124(3):943-952. https://doi.org/10.1172/JCI73316.
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Review Series

Emerging roles of lymphatic endothelium in regulating adaptive immunity

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Abstract

Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function.

Authors

Catherine M. Card, Shann S. Yu, Melody A. Swartz

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Usage data is cumulative from May 2021 through May 2022.

Usage JCI PMC
Text version 1,455 130
PDF 187 41
Figure 219 1
Table 218 0
Citation downloads 12 0
Totals 2,091 172
Total Views 2,263
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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