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Usage Information

Antifibrotic vitamin D analogs
Joseph V. Bonventre
Joseph V. Bonventre
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Commentary

Antifibrotic vitamin D analogs

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Abstract

Chronic kidney disease is associated with progressive kidney fibrosis, which disrupts normal kidney function. There is a great need for treatments to reduce renal fibrosis. In this issue of the JCI, Ito and colleagues report the development of synthetic ligands of the vitamin D receptor that target the TGF-β–SMAD signaling pathway, which is known to regulate fibrosis-associated gene expression, without inducing VDR-associated genes. These ligands ameliorated renal fibrosis in two different mouse models. This study justifies further investigation of these and related compounds for treatment of humans with chronic kidney disease or other diseases characterized by fibrosis.

Authors

Joseph V. Bonventre

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
Text version 753 19
PDF 312 12
Figure 154 0
Citation downloads 185 0
Totals 1,404 31
Total Views 1,435
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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