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Usage Information

Clostridium difficile and the microbiota
Anna M. Seekatz, Vincent B. Young
Anna M. Seekatz, Vincent B. Young
Published July 18, 2014
Citation Information: J Clin Invest. 2014;124(10):4182-4189. https://doi.org/10.1172/JCI72336.
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Review Review Series

Clostridium difficile and the microbiota

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Abstract

Clostridium difficile infection (CDI) is the leading health care–associated illness. Both human and animal models have demonstrated the importance of the gut microbiota’s capability of providing colonization resistance against C. difficile. Risk factors for disease development include antibiotic use, which disrupts the gut microbiota, leading to the loss of colonization resistance and subsequent CDI. Identification of the specific microbes capable of restoring this function remains elusive. Future studies directed at how microbial communities influence the metabolic environment may help elucidate the role of the microbiota in disease development. These findings will improve current biotherapeutics for patients with CDI, particularly those with recurrent disease.

Authors

Anna M. Seekatz, Vincent B. Young

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Usage data is cumulative from January 2020 through January 2021.

Usage JCI PMC
Text version 1,616 1,159
PDF 209 1,360
Figure 485 0
Table 44 0
Supplemental data 0 40
Citation downloads 60 0
Totals 2,414 2,559
Total Views 4,973
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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