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Usage Information

The contributory role of gut microbiota in cardiovascular disease
W.H. Wilson Tang, Stanley L. Hazen
W.H. Wilson Tang, Stanley L. Hazen
Published October 1, 2014
Citation Information: J Clin Invest. 2014;124(10):4204-4211. https://doi.org/10.1172/JCI72331.
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Review

The contributory role of gut microbiota in cardiovascular disease

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Abstract

Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota–dependent formation of TMA and host hepatic flavin monooxygenase 3–dependent (FMO3-dependent) formation of TMA–N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.

Authors

W.H. Wilson Tang, Stanley L. Hazen

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 2,698 383
PDF 192 158
Figure 302 11
Citation downloads 108 0
Totals 3,300 552
Total Views 3,852
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