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Usage Information

Therapeutic translation in acute kidney injury: the epithelial/endothelial axis
Bruce A. Molitoris
Bruce A. Molitoris
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Review Series

Therapeutic translation in acute kidney injury: the epithelial/endothelial axis

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Abstract

Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is also a documented conversion to and acceleration of chronic kidney disease to end-stage renal disease. The multifactorial nature of AKI etiologies and pathophysiology and the lack of diagnostic techniques have hindered translation of preclinical success. An evolving understanding of epithelial, endothelial, and inflammatory cell interactions and individualization of care will result in the eventual development of effective therapeutic strategies. This review focuses on epithelial and endothelial injury mediators, interactions, and targets for therapy.

Authors

Bruce A. Molitoris

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Usage data is cumulative from March 2025 through March 2026.

Usage JCI PMC
Text version 1,322 89
PDF 170 8
Figure 288 5
Supplemental data 207 0
Citation downloads 101 0
Totals 2,088 102
Total Views 2,190
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ISSN: 0021-9738 (print), 1558-8238 (online)

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