The induction of autophagy in the mammalian heart during the perinatal period is an essential adaptation required to survive early neonatal starvation; however, the mechanisms that mediate autophagy suppression once feeding is established are not known. Insulin signaling in the heart is transduced via insulin and IGF-1 receptors (IGF-1Rs). We disrupted insulin and IGF-1R signaling by generating mice with combined cardiomyocyte-specific deletion of
Christian Riehle, Adam R. Wende, Sandra Sena, Karla Maria Pires, Renata Oliveira Pereira, Yi Zhu, Heiko Bugger, Deborah Frank, Jack Bevins, Dong Chen, Cynthia N. Perry, Xiaocheng C. Dong, Steven Valdez, Monika Rech, Xiaoming Sheng, Bart C. Weimer, Roberta A. Gottlieb, Morris F. White, E. Dale Abel
Increased autophagy and apoptosis in CIRS12KO hearts.